Not Financial Advice: Uncirculated ones (no wear) have significant value above face value, up to $125 for the $50 note.
$50.00 in 1974 has the same buying power as $244.27 in 2016.
Use BLS.gov's CPI Inflation Calculator to easily calculate how inflation of the US dollar has changed over the years.
Note: The CPI inflation calculator uses the average Consumer Price Index for a given calendar year. This data represents changes in prices of all goods and services purchased for consumption by urban households. This index value has been calculated every year since 1913. For the current year, the latest monthly index value is used.
For more information, see the guide to available CPI data.
Learn how to calculate inflation rate & base year atr Chron.com.