It appears that the rumors about Biz Markie having Down syndrome or being mentally challenged are not true, as there are no official reports supporting that. Some even say that he's got a speech impediment while others say he suffers from asthma.
Down syndrome is a condition in which a person is born with an extra copy of chromosome 21. People with Down syndrome can have physical problems, as well as intellectual disabilities.
According to reports, rap icon Biz Markie was diagnosed with type 2 diabetes before and it made him realize he needed to make a change. After focusing on his health, Markie lost around 140 pounds in 2014.
Biz Markie eats organic to maintain his slimmer figure, and plans to lose more pounds. The weight loss, he says, has also helped him in his professional life. - US Magazine
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