Yes. Mike Epps and Omar Epps are cousins.
Omar Epps, best known as Dr. Eric Foreman on the television show House, was born on July 20, 1973, in Brooklyn, New York. He studied theater in high school and by age 17 landed a role as a backup singer and dancer for Queen Latifah. In 1992, he starred in his first film Juice with Tupac Shakur.
Mike Epps was born on November 18, 1970 in Indianapolis, Indiana, USA as Michael Elliot Epps.
He built his reputation on the comedy circuit, however, he landed what he considered to be his "biggest break," as he told Jessica Williams-Gibson of the Indianapolis Recorder, in 2000, with a role in the hit film Next Friday.
Of interest, check out 45 Celebrities You Never Knew Were Related, compiled by StyleCaster.com.