On Saturday, September 22, 2012, #4 ranked Florida State beat #10 ranked Clemson by the score of 49-37. This made Florida State 4-0, while Clemson dropped to 3-1. FSU is now 2-0 in the ACC, while Clemson is 0-1 in the ACC.
E.J. Manuel led Florida State with 380 yards passing and 2 Touchdowns passing. Chris Thompson of FSU led all rushers with 103 yards rushing and 2 rushing Touchdowns. Clemson led 21-14 at Halftime, but Florida State then scored 35 points in a 20-minute span in the Second Half.
When they played in 2011, on September 24th, Clemson won 35-30. In 2010, Florida State beat Clemson 16-13 on November 13th. On November 7, 2009, Clemson beat Florida State 40-24. The teams have played 26 times overall, starting in 1970. Florida State leads the all-time series 18-8.