Danielle Colby is married to artist and business partner Alexandre De Meyer. This is her second marriage. She has two children from a previous marriage.
Danielle is best known for appearing on the History Channel's show, American Pickers. She works in the office of the antique shop, Antique Archaeology. She is also a burlesque dancer, using the name "Dannie Diesel".
In January 2013, Danielle opened a clothing boutique, 4 Miles 2 Memphis, in the Wicker Park neighborhood of Chicago. The boutique sells retro-inspired clothing as well as screen-printed T-shirts made by her husband, Alexandre De Meyer.