What medicine completely clears out your sinuses?

Not Medical Advice: The best medicine to clear out your sinuses is a decongestant, typically containing pseudoephedrine or phenylephrine. Saline nasal spray also helps loosen mucus and rinse your sinuses. Popular decongestants include Afrin, Neo-Synephrine and Sudafed.

Avoid antihistamines because they make mucus thick and hard to drain. Also try to avoid foods that irritate mucus-related ailments. This list includes pork, chicken, fish, French fries, processed meat, preserved foods, and refined grains.

It turns out that antibiotics don't work for most sinus infections according to a study published earlier this year in the Journal of the American Medical Association.