Mary-Louise Parker (born on August 2, 1964 in Fort Jackson, South Carolina) has appeared nude in a love scene in season 4, episode 8 of the Showtime TV series Weeds.
This isn't her first time appearing sans clothing, On December 7, 2003 she appeared in HBO's 6.5 hour adaptation of Tony Kushner's Broadway play Angels in America. Parker played Harper Pitt, a drug addicted wife of a "closeted" lawyer, and appeared in the film fully nude.
Parker has appeared in 102 episodes of Weeds, which first aired on August 7, 2005, and just began its 8th season on July 1 of this year
It was just announced that the series will come to an end this year, with the finale airing on September 23, 2012. Parker says that "the finale will make you cry."