Is the actress who plays Amy on The Big Bang Theory the same actress who played lead role in Punky Brewster?

No. Mayim Bialik portrayed Amy Farrah Fowler in The Big Bang Theory, while Soleil Moon Frye played Penelope "Punky" Brewster in Punky Brewster.

Mayim Bialik grew up in San Diego and got her first acting job (Pumpkinhead (1988)) when she was just 12 years old. A number of TV roles followed until in 1990 she was cast in Blossom (1990), the role which made her famous.

Visit her official website at www.mayimbialik.net and follow her on Facebook and on Twitter for updates.

Soleil Moon Frye began acting at the age of two, she became known worldwide as the title character in the Punky Brewster (1984) TV series on NBC.

Get the latest updates about Soleil Moon Frye via her Instagram and Twitter accounts.

Friday, December 02 2016
Source: http://www.imdb.com/name/nm0080524/