How long will grapefruit juice stay in my system

Not Medical Advice: What we found is that the half-life of the effects of grapefruit juice is estimated to be around 12 hours, but these effects may last from 4 hours to 24 hours.

It is risky to take medications with grapefruit, as it contains furanocoumarins, which block an enzyme that normally breaks down certain medications in the body.

In an article from WebMD published on November 27, 2012, there are more than 85 drugs that may interact with grapefruit. The number of drugs that may result in potentially fatal side effects when mixed with grapefruit increased from 17 to 43 during the past four years. This equates to more than six new potentially risky drugs a year.

Researchers note that grapefruit interaction is specific to certain drugs and doesn’t necessarily affect an entire drug class. This can allow for grapefruit-friendly options.

But better safe than sorry, if you are to take a medicine, make sure to double check it with your doctor or pharmacist, as it doesn’t really require a lot of grapefruit juice to produce a dangerous interaction.

Check out some tips to help you stay safe with grapefruit interaction at