How far is Oxford, MS from Tupelo, MS?

Oxford, MS from Tupelo, MS is 49.9 miles and would take about 54 minutes to drive via MS-6/US-278 W. Via MS-9 S and MS-6 W/US-278 W it's 55.5 miles and would take 1 hour and 3 minutes to drive. If you choose Interstate 22 W and MS-30 W it's 60.2 miles and would take about 1 hour and 12 minutes to drive. Although they are all pretty close, MS-6 W/US-278 W seems like a slightly better choice.

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